Six sigma in drug design - Old hands or fresh blood?

K. Ramakrishnan asked the question

Will implementation of Six sigma, TQM, ISO improve efficiency or hinder the innovation?
What would be an ideal process or methodology to improve innovation in drug discovery?
What would be the best methodology or way to build an integrated team with good communication and coordination to accelerate both innovation and efficiency in drug discovery?

Might there be a connection to the six degrees of drug design? And what helps more? Old hands or fresh blood? Are people here just playing with buzz-words or can anybody really give some more information about those topics?