Thursday, September 13, 2007

Quotes from the neighbors

==DrugBank continues to offer open access drug information==

The DrugBank database is a freely available, bioinformatics and cheminformatics resource that combines chemical, pharmacological and pharmaceutical drug data with comprehensive drug target (i.e. protein) information. [Chemistry Central]
==Zinc mediated inhibitors==
At pH 8.2 the inhibition constant (Ki) of BABIM for bovine trypsin in 1.0 mM EDTA, pH 8.2, is 19 uM. Addition of Zn²+ at concentration as low as 100 nM increases the affinity of BABIM for trypsin by 3,800 to Ki = 5.0 ± 0.3 nM. Zn²+ alone is a weak inhibitor of trypsin with a Ki of ~ 33 mM at pH 5.5, and ~ 1.0 mM at pH 7.0. [whistling in the wind]
==Why InChIKey?==
... the only problem with InChI is the length of the identifiers and the issues caused by the characters used. This could be solved by having a centralized service that assigned short HTTP URLs for InChIs, ensuring a one to one relationship between InChIs and shorthand URLs. [Jim Downing]
Sounds like TinyURL to me.

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